.NET Process type of profiling allows you to profile any managed application that is started after clicking Run.
If you want dotMemory to track Silverlight applications, check the Profile Silverlight applications option.
After you click Run, the main dotMemory window will appear. From this point on, dotMemory is ready to hook into any managed application that is launched. If more than one application gets launched, you can choose the one you are interested in and drop others.